H-Y antigen in a fertile XY female horse.
نویسندگان
چکیده
The presence of significantly reduced levels of H-Y antigen in the blood of an XY mare is consistent with the view that H-Y genes comprise a system of testis determinants. Loss or suppression of a critical portion of H-Y genes and subthreshold expression of H-Y antigen could account for a failure of testicular differentiation, thereby allowing a measure of ovarian development in an XY embryo.
منابع مشابه
Abnormality of the X chromosome in human 46,XY female siblings with dysgenetic ovaries.
An abnormal extra band was found on the short arm of the X chromosome in a 46,XY female and in her 46,XY female fetal sibling. Despite presence of the intact Y chromosome, there was no evidence of testicular differentiation in either subject. Production of H-Y antigen was suppressed in both subjects. The data suggest that development of the mammalian testis requires a normal function of the X c...
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ورودعنوان ژورنال:
- Journal of reproduction and fertility
دوره 58 1 شماره
صفحات -
تاریخ انتشار 1980